{"id":190,"date":"2020-11-11T05:06:28","date_gmt":"2020-11-11T05:06:28","guid":{"rendered":"http:\/\/metascape.org\/blog\/?p=190"},"modified":"2020-11-29T19:18:04","modified_gmt":"2020-11-29T19:18:04","slug":"coronascape-%e4%b8%bacovid-19%e7%a0%94%e7%a9%b6%e7%89%b9%e5%88%b6%e7%9a%84%e5%9f%ba%e5%9b%a0%e5%88%97%e8%a1%a8%e6%af%94%e8%be%83%e5%b7%a5%e5%85%b7","status":"publish","type":"post","link":"https:\/\/metascape.org\/blog\/?p=190","title":{"rendered":"Coronascape – \u4e3aCOVID-19\u7814\u7a76\u7279\u5236\u7684\u57fa\u56e0\u5217\u8868\u6bd4\u8f83\u5de5\u5177"},"content":{"rendered":"\n

\u7b80\u4ecb<\/h2>\n\n\n\n

COVID\u7814\u7a76\u8005\u901a\u8fc7\u9ad8\u901a\u91cf\u7684\u7ec4\u5b66\u5b9e\u9a8c\u83b7\u53d6\u4e86\u4e00\u7ec4\u57fa\u56e0\u5217\u8868\u540e\u5982\u4f55\u8fdb\u884c\u8fdb\u4e00\u6b65\u7684\u6570\u636e\u5206\u6790\u5462\uff1f\u9ad8\u901a\u91cf\u6570\u636e\u5f80\u5f80\u91cd\u590d\u6b21\u6570\u5c11\uff0c\u6570\u636e\u566a\u58f0\u9ad8\uff0c\u60f3\u8981\u53ea\u4ece\u81ea\u5df1\u5355\u4e00\u7684\u57fa\u56e0\u5217\u8868\u4e2d\u62bd\u53d6\u5230\u4e0e\u751f\u7269\u7cfb\u7edf\u771f\u5b9e\u76f8\u5173\u7684\u5206\u5b50\u901a\u8def\u5c31\u4f1a\u56f0\u96be\u4e00\u4e9b\u3002\u6240\u4ee5\u6211\u4eec\u9996\u5148\u5e0c\u671b\u5c06\u4fe1\u53f7\u653e\u5927\uff0c\u5c31\u662f\u8981\u627e\u5230\u5176\u4ed6\u5df2\u7ecf\u53d1\u8868\u6216\u5c06\u8981\u53d1\u8868\u7684\u5728\u7c7b\u4f3c\u5b9e\u9a8c\u6761\u4ef6\u4e0b\u83b7\u5f97\u7684\u57fa\u56e0\u5217\u8868\u7528\u4e8e\u5bf9\u7167\u3002\u901a\u8fc7\u6bd4\u5bf9\uff0c\u771f\u5b9e\u7684\u4fe1\u53f7\u5f97\u4ee5\u589e\u5f3a\uff0c\u7ed3\u8bba\u4ece\u7edf\u8ba1\u610f\u4e49\u4e0a\u5c31\u66f4\u52a0\u53ef\u9760\u3002\u76ee\u524dCOVID\u7814\u7a76\u6587\u732e\u7684\u6570\u91cf\u5728\u98de\u901f\u589e\u957f\uff0c\u7814\u7a76\u8005\u8981\u53bb\u9605\u8bfb\u7b5b\u67e5\u627e\u5230\u76f8\u4f3c\u7684\u7ec4\u5b66\u5b9e\u9a8c\u8bbe\u8ba1\uff0c\u5e76\u4e14\u5bf9\u539f\u59cb\u6570\u636e\u8fdb\u884c\u9884\u5904\u7406\u4ee5\u83b7\u5f97\u53ef\u4ee5\u7528\u4e8e\u6bd4\u7167\u7684\u57fa\u56e0\u5217\u8868\u5176\u5b9e\u4e0d\u662f\u4e00\u4ef6\u553e\u624b\u53ef\u53ca\u7684\u4e8b\u3002Coronascape<\/a> (http:\/\/coronascape.org) \u7684\u76ee\u7684\u5c31\u662f\u4e3a\u4e86\u5e2e\u52a9COVID\u7814\u7a76\u4eba\u5458\u89e3\u51b3\u8fd9\u4e00\u96be\u9898\u3002<\/p>\n\n\n\n

Coronascape\u662f\u7531Sanford Burnham Prebys Medical Discovery Institute, Novartis\u548cUCSD\u5408\u4f5c\u5171\u540c\u5f00\u53d1\u7684\u65b0\u51a0\u75c5\u6bd2\u7ec4\u5b66\u516c\u5171\u6570\u636e\u5e93\u3002Coronascape\u6536\u5f55\u4e8620\u7bc7\u6587\u7ae0360\u591a\u4e2aSARS-CoV-2\u76f8\u5173\u7684\u57fa\u56e0\u6216\u8005\u86cb\u767d\u6570\u636e\u96c6\uff0c\u6db5\u76d6\u4e86\u4e03\u79cd\u4e0d\u540c\u7684\u7ec4\u5b66\u6280\u672f\uff0c\u5305\u62ec\u8f6c\u5f55\u7ec4\uff08RNA-Seq\u548cscRNASeq\uff09\uff0c\u86cb\u767d\u8d28\u7ec4\uff0c\u78f7\u9178\u5316\u86cb\u767d\u8d28\u7ec4\uff0c\u6cdb\u7d20\u7ec4\u548c\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\u7ec4\u3002 \u4f7f\u7528Coronascape\u6570\u636e\u5e93\u53ef\u4ee5\u5168\u9762\u6df1\u5165\u7684\u4e86\u89e3\u5404\u79cd\u5bbf\u4e3b\u7ec6\u80de\u548c\u7ec4\u7ec7\u4e2dSARS-CoV-2\u611f\u67d3\u540e\u7684\u57fa\u56e0\u8868\u8fbe\u53d8\u5316\uff0c\u86cb\u767d\u8868\u8fbe\u4fee\u9970\u4ee5\u53ca\u76f8\u4e92\u4f5c\u7528\u5173\u7cfb\u3002\u7528\u6237\u53ea\u8981\u5c06\u81ea\u5df1\u7684\u57fa\u56e0\u5217\u8868\u8f93\u5165Coronascape\u8fdb\u884cSimilarity Search\uff0cCoronascape\u4f1a\u63a8\u8350\u6570\u636e\u5e93\u91cc\u76f8\u4f3c\u7684\u57fa\u56e0\u5217\u8868\u3002\u5f53\u7136\u7528\u6237\u4e5f\u53ef\u4ee5\u901a\u8fc7\u5173\u952e\u8bcd\u641c\u7d22\u4ee5\u83b7\u53d6\u53c2\u7167\u7ec4\u3002<\/p>\n\n\n\n

\u83b7\u53d6\u591a\u7ec4\u57fa\u56e0\u5217\u8868\u540e\uff0c\u7528\u6237\u8981\u901a\u8fc7\u5206\u5b50\u901a\u8def\u5206\u6790\u548c\u86cb\u767d\u7f51\u7edc\u5206\u6790\u627e\u51fa\u6570\u636e\u80cc\u540e\u7684\u5206\u5b50\u673a\u7406\uff0c\u5e76\u5bf9\u5206\u6790\u7ed3\u679c\u5236\u6210\u53ef\u4ee5\u5e2e\u52a9\u9610\u660e\u751f\u7269\u539f\u7406\u7684\u56fe\u8868\u3002\u8fd9\u4e9b\u6b63\u662fMetascape\u7684\u5f3a\u9879\uff0c\u800cCoronascape\u5728\u540e\u53f0\u662f\u548cMetascape\u65e0\u7f1d\u8854\u63a5\u7684\u3002Coronascape\u901a\u8fc7\u975e\u5e38\u53cb\u597d\u95f4\u7684\u7528\u6237\u64cd\u4f5c\u754c\u9762\uff0c\u8ba9\u7528\u6237\u63d0\u4ea4\u81ea\u5df1\u7684\u57fa\u56e0\u6570\u636e\u4e0e\u516c\u5171\u6570\u636e\u8fdb\u884c\u6bd4\u8f83\uff0c\u518d\u5bf9\u751f\u6210\u7684\u5217\u8868\u7ec4\u5e94\u7528\u6210\u719f\u7684\u7cfb\u7edf\u751f\u7269\u5b66\u7f51\u7ad9Metascape\u8fdb\u884c\u4fe1\u53f7\u901a\u8def\uff0cGene Ontology\uff0c\u7f51\u7edc\u5206\u6790\u7b49\u6df1\u5165\u7684\u6570\u636e\u5206\u6790\u3002\u5229\u7528Coronascape\uff0c\u7528\u6237\u53ef\u4ee5\u4ece\u5355\u4e00\u57fa\u56e0\u5217\u8868\u8f6c\u5316\u4e3a\u591a\u4e2a\u5217\u8868\uff0c\u518d\u83b7\u53d6\u56fe\u6587\u5e76\u8302\u7684meta-analysis\u5206\u6790\u62a5\u544a\u4e00\u6c14\u5475\u6210\u3002\u6ca1\u6709\u81ea\u5df1\u5b9e\u9a8c\u6570\u636e\u7684\u7528\u6237\u4e5f\u53ef\u4ee5\u76f4\u63a5\u5bf9Coronascape\u4e2d\u5df2\u6709\u7684\u6570\u636e\u8fdb\u884c\u4e8c\u6b21\u5206\u6790\u3002<\/p>\n\n\n\n

\u7531\u4e8eCoronascape\u521a\u521a\u63a8\u51fa\uff0c\u8fd8\u6ca1\u6709\u53d1\u8868\u7684\u6210\u679c\u3002\u4e0d\u8fc7\u5df2\u7ecf\u6709\u5e94\u7528\u5b9e\u4f8b\u4e0a\u4f20\u5230Biorxiv (https:\/\/www.biorxiv.org\/content\/10.1101\/2020.08.18.256776v1<\/a>)\u3002\u6587\u7ae0\u4f5c\u8005\u901a\u8fc7\u5bf9\u6bd4Coronascape\u4e2d\u7684\u6570\u636e\uff0c\u6df1\u5165\u7814\u7a76\u4e86SARS-COV-2\u7684ORF9C\u86cb\u767d\u5728\u5bbf\u4e3b\u4e2d\u8f6c\u5f55\u7ec4\u548c\u86cb\u767d\u7ec4\u7b49\u4e0e\u5df2\u53d1\u8868\u7684\u516c\u5171\u6570\u636e\u7684\u5f02\u540c\uff0c\u53d1\u73b0ORF9C\u5355\u4e2a\u86cb\u767d\u5373\u53ef\u5b9e\u73b0\u5168\u75c5\u6bd2\u611f\u67d3\u7ec6\u80de\u548c\u80ba\u90e8\u7ec4\u7ec7\u65f6\u7684\u514d\u75ab\u6291\u5236\u4ee5\u53ca\u7ec6\u80de\u56e0\u5b50\u6fc0\u6d3b\u529f\u80fd\uff0c\u63ed\u793a\u4e86ORF9C\u53ef\u80fd\u65f6\u75c5\u6bd2\u4e0e\u5bbf\u4e3b\u76f8\u4e92\u4f5c\u7528\u7684\u5173\u952e\u86cb\u767d\u4e4b\u4e00\u3002\u8fd9\u662f\u5bf9\u4f7f\u7528Coronascape\u8fdb\u884cCOV-2\u591a\u91cd\u7ec4\u5b66\u7814\u7a76\u7684\u975e\u5e38\u597d\u7684\u4e00\u4e2a\u793a\u4f8b\u3002<\/p>\n\n\n\n

\u4e0b\u9762\u901a\u8fc7\u4e00\u4e9b\u5b9e\u4f8b\u4ecb\u7ecd\u4e00\u4e0bCoronascape\u7684\u7528\u6cd5\u3002<\/p>\n\n\n\n

\u793a\u4f8b\u4e00\uff1a\u901a\u8fc7\u7528\u6237\u7684\u57fa\u56e0\u5217\u8868\u4eceCoronascape\u67e5\u627e\u76f8\u4f3c\u7684\u57fa\u56e0\u5217\u8868<\/h2>\n\n\n\n

1. \u5c06\u60a8\u7684\u57fa\u56e0\u5217\u8868\u7c98\u8d34\u5230\u201cUser\u2019s Gene List\u201d\u4e2d\u3002<\/p>\n\n\n\n

2. \u5728\u201cRecommendation\u201d\u4e2d\uff0c\u5355\u51fb\u201cSimilarity Search\u201d\u3002<\/p>\n\n\n\n

3. \u4e0e\u7528\u6237\u7684\u57fa\u56e0\u5217\u8868\u76f8\u6bd4\uff0c\u60a8\u5c06\u80fd\u591f\u770b\u5230\u6309\u76f8\u4f3c\u6027\u6392\u540d\u7684\u57fa\u56e0\u5217\u8868\u3002\u60a8\u53ef\u4ee5\u5355\u51fb\u201cDownload Similarity\u201d\u4ee5\u83b7\u5f97\u8be6\u7ec6\u7684\u57fa\u56e0\u5217\u8868\u3002<\/p>\n\n\n\n

4. \u60a8\u53ef\u4ee5\u5355\u51fb\u201cUse Selected\u201d\u6216\u201cAppend Selected\u201d\u4ee5\u5c06\u9009\u5b9a\u7684\u57fa\u56e0\u5217\u8868\u6dfb\u52a0\u5230\u201c\u8981\u6bd4\u8f83\u7684\u53c2\u7167\u5217\u8868\u201d\u4e2d\u3002<\/p>\n\n\n\n

5. \u6dfb\u52a0\u57fa\u56e0\u5217\u8868\u540e\uff0c\u5355\u51fb\u201c Metascape Analysis\u201d\u4ee5\u5bf9\u7528\u6237\u7684\u57fa\u56e0\u5217\u8868\u548c\u4eceCoronascape\u4e2d\u9009\u62e9\u7684\u57fa\u56e0\u5217\u8868\u8fdb\u884c\u7cfb\u7edf\u5206\u6790\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u793a\u4f8b\u4e8c\uff1a\u5c06\u7528\u6237\u7684\u57fa\u56e0\u5217\u8868\u4e0e\u7279\u5b9a\u516c\u5171\u7814\u7a76\u7684\u57fa\u56e0\u5217\u8868\u8fdb\u884c\u6bd4\u8f83<\/h2>\n\n\n\n

1. \u5c06\u60a8\u7684\u57fa\u56e0\u5217\u8868\u7c98\u8d34\u5230\u201cUser\u2019s Gene List\u201d\u4e2d\u3002<\/p>\n\n\n\n

2. \u5728\u201cBrowse All\u201d\u4e2d\uff0c\u67e5\u627e\u60a8\u611f\u5174\u8da3\u7684\u7814\u7a76\u3002\u5355\u51fb\u60a8\u8981\u6dfb\u52a0\u5230\u53c2\u8003\u5217\u8868\u7684\u57fa\u56e0\u5217\u8868\u3002<\/p>\n\n\n\n

3. \u5355\u51fb\u201cUse Selected\u201d\u5c06\u57fa\u56e0\u5217\u8868\u6dfb\u52a0\u5230\u53c2\u8003\u5217\u8868\uff0c\u6216\u5355\u51fb\u201cAppend Selected\u201d\u4ee5\u6dfb\u52a0\u5230\u73b0\u6709\u57fa\u56e0\u5217\u8868\u3002<\/p>\n\n\n\n

4. \u6b64\u6b65\u9aa4\u53ef\u4ee5\u8df3\u8fc7\u3002\u5982\u679c\u8981\u4fdd\u5b58\u9009\u5b9a\u7684\u57fa\u56e0\u5217\u8868\u4ee5\u5907\u5c06\u6765\u4f7f\u7528\uff0c\u8bf7\u5355\u51fb\u201cDownload Reference List\u201d\u3002\u8be5\u5217\u8868\u53ef\u4ee5\u76f4\u63a5\u63d0\u4ea4\u7ed9Metascape\u8fdb\u884c\u5206\u6790\u3002<\/p>\n\n\n\n

5. \u5355\u51fb\u201c Metascape Analysis\u201d\u6267\u884c\u7cfb\u7edf\u5206\u6790\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u793a\u4f8b\u4e09\uff1a\u5c06\u7528\u6237\u7684\u57fa\u56e0\u5217\u8868\u4e0eA549\u7ec6\u80de\u7cfb\u7684\u76f8\u4e92\u4f5c\u7528\u7ec4\u6570\u636e\u8fdb\u884c\u6bd4\u8f83<\/h2>\n\n\n\n

1. \u5c06\u60a8\u7684\u57fa\u56e0\u5217\u8868\u7c98\u8d34\u5230\u201cUser\u2019s Gene List\u201d\u4e2d\u3002<\/p>\n\n\n\n

2. \u5728\u201cSearch\u201d\u7684\u201cTechnology\u201d\u4e2d\uff0c\u9009\u62e9\u201c Interactome\u201d\uff0c\u5728\u201cSource\u201d\u4e2d\uff0c\u9009\u62e9\u201c A549\u201d\u3002<\/p>\n\n\n\n

3. \u5355\u51fb\u201cSearch\u201d\u4ee5\u627e\u5230\u5339\u914d\u7684\u57fa\u56e0\u5217\u8868\u3002<\/p>\n\n\n\n

4. \u5355\u51fb\u201cUse Selected\u201d\u5c06\u57fa\u56e0\u5217\u8868\u6dfb\u52a0\u5230\u53c2\u8003\u5217\u8868\uff0c\u6216\u5355\u51fb\u201cAppend Selected\u201d\u6dfb\u52a0\u5230\u73b0\u6709\u7684\u57fa\u56e0\u5217\u8868\u3002<\/p>\n\n\n\n

5. \u5355\u51fb\u201c Metascape Analysis\u201d\u6267\u884c\u7cfb\u7edf\u5206\u6790\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u793a\u4f8b\u56db\uff1a\u5bf9Coronascape\u4e2d\u7684\u57fa\u56e0\u5217\u8868\u6267\u884cMetascape\u91cd\u65b0\u5206\u6790<\/h2>\n\n\n\n

1. \u5c06\u60a8\u7684\u57fa\u56e0\u5217\u8868\u7c98\u8d34\u5230\u201cUser\u2019s Gene List\u201d\u4e2d<\/p>\n\n\n\n

2. \u4f7f\u7528\u201c Recommendation\u201d\uff0c\u201c Search\u201d\uff0c\u201c GO Heatmap\u201d\u6216\u201c Browse All\u201d\u529f\u80fd\u5c06\u9009\u5b9a\u7684\u57fa\u56e0\u5217\u8868\u6dfb\u52a0\u5230\u201c Reference Lists to Compare\u201d\u4e2d\u3002<\/p>\n\n\n\n

3. \u5355\u51fb\u5e26\u6709\u6216\u4e0d\u5e26\u6709\u7528\u6237\u57fa\u56e0\u5217\u8868\u7684Metascape\u8fdb\u884c\u7cfb\u7edf\u5206\u6790\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u7b80\u4ecb 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(http:\/\/coronascape.org) \u7684\u76ee\u7684\u5c31\u662f\u4e3a\u4e86\u5e2e\u52a9COVID\u7814\u7a76\u4eba\u5458\u89e3\u51b3\u8fd9\u4e00\u96be\u9898\u3002 Coronascape\u662f\u7531Sanford Burnham Prebys Medical Discovery Institute, Novartis\u548cUCSD\u5408\u4f5c\u5171\u540c\u5f00\u53d1\u7684\u65b0\u51a0\u75c5\u6bd2\u7ec4\u5b66\u516c\u5171\u6570\u636e\u5e93\u3002Coronascape\u6536\u5f55\u4e8620\u7bc7\u6587\u7ae0360\u591a\u4e2aSARS-CoV-2\u76f8\u5173\u7684\u57fa\u56e0\u6216\u8005\u86cb\u767d\u6570\u636e\u96c6\uff0c\u6db5\u76d6\u4e86\u4e03\u79cd\u4e0d\u540c\u7684\u7ec4\u5b66\u6280\u672f\uff0c\u5305\u62ec\u8f6c\u5f55\u7ec4\uff08RNA-Seq\u548cscRNASeq\uff09\uff0c\u86cb\u767d\u8d28\u7ec4\uff0c\u78f7\u9178\u5316\u86cb\u767d\u8d28\u7ec4\uff0c\u6cdb\u7d20\u7ec4\u548c\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\u7ec4\u3002 \u4f7f\u7528Coronascape\u6570\u636e\u5e93\u53ef\u4ee5\u5168\u9762\u6df1\u5165\u7684\u4e86\u89e3\u5404\u79cd\u5bbf\u4e3b\u7ec6\u80de\u548c\u7ec4\u7ec7\u4e2dSARS-CoV-2\u611f\u67d3\u540e\u7684\u57fa\u56e0\u8868\u8fbe\u53d8\u5316\uff0c\u86cb\u767d\u8868\u8fbe\u4fee\u9970\u4ee5\u53ca\u76f8\u4e92\u4f5c\u7528\u5173\u7cfb\u3002\u7528\u6237\u53ea\u8981\u5c06\u81ea\u5df1\u7684\u57fa\u56e0\u5217\u8868\u8f93\u5165Coronascape\u8fdb\u884cSimilarity Search\uff0cCoronascape\u4f1a\u63a8\u8350\u6570\u636e\u5e93\u91cc\u76f8\u4f3c\u7684\u57fa\u56e0\u5217\u8868\u3002\u5f53\u7136\u7528\u6237\u4e5f\u53ef\u4ee5\u901a\u8fc7\u5173\u952e\u8bcd\u641c\u7d22\u4ee5\u83b7\u53d6\u53c2\u7167\u7ec4\u3002 \u83b7\u53d6\u591a\u7ec4\u57fa\u56e0\u5217\u8868\u540e\uff0c\u7528\u6237\u8981\u901a\u8fc7\u5206\u5b50\u901a\u8def\u5206\u6790\u548c\u86cb\u767d\u7f51\u7edc\u5206\u6790\u627e\u51fa\u6570\u636e\u80cc\u540e\u7684\u5206\u5b50\u673a\u7406\uff0c\u5e76\u5bf9\u5206\u6790\u7ed3\u679c\u5236\u6210\u53ef\u4ee5\u5e2e\u52a9\u9610\u660e\u751f\u7269\u539f\u7406\u7684\u56fe\u8868\u3002\u8fd9\u4e9b\u6b63\u662fMetascape\u7684\u5f3a\u9879\uff0c\u800cCoronascape\u5728\u540e\u53f0\u662f\u548cMetascape\u65e0\u7f1d\u8854\u63a5\u7684\u3002Coronascape\u901a\u8fc7\u975e\u5e38\u53cb\u597d\u95f4\u7684\u7528\u6237\u64cd\u4f5c\u754c\u9762\uff0c\u8ba9\u7528\u6237\u63d0\u4ea4\u81ea\u5df1\u7684\u57fa\u56e0\u6570\u636e\u4e0e\u516c\u5171\u6570\u636e\u8fdb\u884c\u6bd4\u8f83\uff0c\u518d\u5bf9\u751f\u6210\u7684\u5217\u8868\u7ec4\u5e94\u7528\u6210\u719f\u7684\u7cfb\u7edf\u751f\u7269\u5b66\u7f51\u7ad9Metascape\u8fdb\u884c\u4fe1\u53f7\u901a\u8def\uff0cGene Ontology\uff0c\u7f51\u7edc\u5206\u6790\u7b49\u6df1\u5165\u7684\u6570\u636e\u5206\u6790\u3002\u5229\u7528Coronascape\uff0c\u7528\u6237\u53ef\u4ee5\u4ece\u5355\u4e00\u57fa\u56e0\u5217\u8868\u8f6c\u5316\u4e3a\u591a\u4e2a\u5217\u8868\uff0c\u518d\u83b7\u53d6\u56fe\u6587\u5e76\u8302\u7684meta-analysis\u5206\u6790\u62a5\u544a\u4e00\u6c14\u5475\u6210\u3002\u6ca1\u6709\u81ea\u5df1\u5b9e\u9a8c\u6570\u636e\u7684\u7528\u6237\u4e5f\u53ef\u4ee5\u76f4\u63a5\u5bf9Coronascape\u4e2d\u5df2\u6709\u7684\u6570\u636e\u8fdb\u884c\u4e8c\u6b21\u5206\u6790\u3002 \u7531\u4e8eCoronascape\u521a\u521a\u63a8\u51fa\uff0c\u8fd8\u6ca1\u6709\u53d1\u8868\u7684\u6210\u679c\u3002\u4e0d\u8fc7\u5df2\u7ecf\u6709\u5e94\u7528\u5b9e\u4f8b\u4e0a\u4f20\u5230Biorxiv (https:\/\/www.biorxiv.org\/content\/10.1101\/2020.08.18.256776v1)\u3002\u6587\u7ae0\u4f5c\u8005\u901a\u8fc7\u5bf9\u6bd4Coronascape\u4e2d\u7684\u6570\u636e\uff0c\u6df1\u5165\u7814\u7a76\u4e86SARS-COV-2\u7684ORF9C\u86cb\u767d\u5728\u5bbf\u4e3b\u4e2d\u8f6c\u5f55\u7ec4\u548c\u86cb\u767d\u7ec4\u7b49\u4e0e\u5df2\u53d1\u8868\u7684\u516c\u5171\u6570\u636e\u7684\u5f02\u540c\uff0c\u53d1\u73b0ORF9C\u5355\u4e2a\u86cb\u767d\u5373\u53ef\u5b9e\u73b0\u5168\u75c5\u6bd2\u611f\u67d3\u7ec6\u80de\u548c\u80ba\u90e8\u7ec4\u7ec7\u65f6\u7684\u514d\u75ab\u6291\u5236\u4ee5\u53ca\u7ec6\u80de\u56e0\u5b50\u6fc0\u6d3b\u529f\u80fd\uff0c\u63ed\u793a\u4e86ORF9C\u53ef\u80fd\u65f6\u75c5\u6bd2\u4e0e\u5bbf\u4e3b\u76f8\u4e92\u4f5c\u7528\u7684\u5173\u952e\u86cb\u767d\u4e4b\u4e00\u3002\u8fd9\u662f\u5bf9\u4f7f\u7528Coronascape\u8fdb\u884cCOV-2\u591a\u91cd\u7ec4\u5b66\u7814\u7a76\u7684\u975e\u5e38\u597d\u7684\u4e00\u4e2a\u793a\u4f8b\u3002 \u4e0b\u9762\u901a\u8fc7\u4e00\u4e9b\u5b9e\u4f8b\u4ecb\u7ecd\u4e00\u4e0bCoronascape\u7684\u7528\u6cd5\u3002 \u793a\u4f8b\u4e00\uff1a\u901a\u8fc7\u7528\u6237\u7684\u57fa\u56e0\u5217\u8868\u4eceCoronascape\u67e5\u627e\u76f8\u4f3c\u7684\u57fa\u56e0\u5217\u8868 1. \u5c06\u60a8\u7684\u57fa\u56e0\u5217\u8868\u7c98\u8d34\u5230\u201cUser\u2019s Gene List\u201d\u4e2d\u3002 2. \u5728\u201cRecommendation\u201d\u4e2d\uff0c\u5355\u51fb\u201cSimilarity Search\u201d\u3002 3. \u4e0e\u7528\u6237\u7684\u57fa\u56e0\u5217\u8868\u76f8\u6bd4\uff0c\u60a8\u5c06\u80fd\u591f\u770b\u5230\u6309\u76f8\u4f3c\u6027\u6392\u540d\u7684\u57fa\u56e0\u5217\u8868\u3002\u60a8\u53ef\u4ee5\u5355\u51fb\u201cDownload Similarity\u201d\u4ee5\u83b7\u5f97\u8be6\u7ec6\u7684\u57fa\u56e0\u5217\u8868\u3002 4. \u60a8\u53ef\u4ee5\u5355\u51fb\u201cUse Selected\u201d\u6216\u201cAppend Selected\u201d\u4ee5\u5c06\u9009\u5b9a\u7684\u57fa\u56e0\u5217\u8868\u6dfb\u52a0\u5230\u201c\u8981\u6bd4\u8f83\u7684\u53c2\u7167\u5217\u8868\u201d\u4e2d\u3002 5. \u6dfb\u52a0\u57fa\u56e0\u5217\u8868\u540e\uff0c\u5355\u51fb\u201c Metascape Analysis\u201d\u4ee5\u5bf9\u7528\u6237\u7684\u57fa\u56e0\u5217\u8868\u548c\u4eceCoronascape\u4e2d\u9009\u62e9\u7684\u57fa\u56e0\u5217\u8868\u8fdb\u884c\u7cfb\u7edf\u5206\u6790\u3002 \u793a\u4f8b\u4e8c\uff1a\u5c06\u7528\u6237\u7684\u57fa\u56e0\u5217\u8868\u4e0e\u7279\u5b9a\u516c\u5171\u7814\u7a76\u7684\u57fa\u56e0\u5217\u8868\u8fdb\u884c\u6bd4\u8f83 1. \u5c06\u60a8\u7684\u57fa\u56e0\u5217\u8868\u7c98\u8d34\u5230\u201cUser\u2019s … Continue reading 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