{"id":102,"date":"2019-04-06T16:55:39","date_gmt":"2019-04-06T16:55:39","guid":{"rendered":"http:\/\/metascape.org\/blog\/?p=102"},"modified":"2019-07-06T06:15:32","modified_gmt":"2019-07-06T06:15:32","slug":"metascape%e6%98%af%e4%b8%93%e9%97%a8%e4%b8%ba%e7%94%9f%e7%89%a9%e5%ad%a6%e8%80%85%e8%ae%be%e8%ae%a1%e7%9a%84%e5%9f%ba%e5%9b%a0%e5%88%97%e8%a1%a8%e5%88%86%e6%9e%90%e7%bd%91%e7%ab%99","status":"publish","type":"post","link":"https:\/\/metascape.org\/blog\/?p=102","title":{"rendered":"Metascape\u662f\u4e13\u95e8\u4e3a\u751f\u7269\u5b66\u8005\u8bbe\u8ba1\u7684\u57fa\u56e0\u5217\u8868\u5206\u6790\u7f51\u7ad9"},"content":{"rendered":"\n

\u6b22\u8fce\u8f6c\u8f7d<\/p>\n\n\n\n

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\u56fe1. Metascape\u81ea\u52a8\u751f\u6210\u7684\u5206\u6790\u7ed3\u679c\u3002<\/figcaption><\/figure><\/div>\n\n\n\n

\u56fe2\u4ee5121\u4e2a\u6d41\u611f\u5bbf\u4e3b\u56e0\u5b50\u4e3a\u4f8b\uff0c\u8bf4\u660e\u4e86Metascape\u5bf9\u5355\u4e00\u57fa\u56e0\u5217\u8868\u7684\u4e3b\u8981\u5206\u6790\u7ed3\u679c\u3002<\/p>\n\n\n\n

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\u56fe2. a\uff09 Metascape\u53bb\u9664\u529f\u80fd\u5197\u4f59\u7684\u5bcc\u96c6\u901a\u8def\uff0c\u7528\u7b80\u5355\u660e\u4e86\u7684bargraph\u663e\u793a\u51fa\u6700\u4e3b\u8981\u7684\u5b9e\u9a8c\u7ed3\u679c\uff1bb\uff09\u5bcc\u96c6\u751f\u7269\u901a\u8def\u53ef\u4ee5\u4ee5\u7f51\u7edc\u65b9\u5f0f\u8868\u73b0\uff0c\u8fd9\u66f4\u5229\u4e8e\u7406\u89e3\u901a\u8def\u6216\u751f\u7269\u8fc7\u7a0b\u4e4b\u95f4\u7684\u5173\u7cfb\uff1bc\uff09Metascape\u81ea\u52a8\u62bd\u53d6\u63d0\u4ea4\u5217\u8868\u4e2d\u8574\u542b\u7684\u86cb\u767d\u8d28\u4e92\u4f5c\u7528\u7f51\u7edc\uff1bd\uff09\u4e3a\u4e86\u66f4\u5bb9\u6613\u7406\u89e3\u8fd9\u4e00\u7f51\u7edc\uff0cMetascape\u91c7\u7528\u6210\u719f\u7684MCODE\u7b97\u6cd5\u5bfb\u627e\u7f51\u7edc\u4e2d\u7684\u5bc6\u96c6\u8054\u7ed3\u7684\u86cb\u767d\u8d28\u7fa4\uff0c\u5e76\u5bf9\u6bcf\u4e2a\u7fa4\u7684\u751f\u7269\u529f\u80fd\u8fdb\u884c\u6ce8\u91ca\u3002<\/figcaption><\/figure>\n\n\n\n

\u5f53\u4ee3\u7684\u591a\u7ec4\u5b66\u5b9e\u9a8c\u5f80\u5f80\u751f\u6210\u591a\u4e2a\u57fa\u56e0\u5217\u8868\uff0c\u76ee\u524d\u7684\u7f51\u7edc\u5de5\u5177\u5f88\u5c11\u80fd\u540c\u65f6\u5206\u6790\u5e76\u6574\u5408\u591a\u57fa\u56e0\u5217\u8868\uff0c\u800c\u8fd9\u6070\u6070\u662fMetascape\u7684\u957f\u5904\u4e4b\u4e00\u3002\u5176\u5b9eMetascape\u7684”meta”\u5c31\u662f\u6765\u6e90\u4e8e\u591a\u5217\u8868\u7684meta-analysis\u3002\u56fe3\u4ee5\u4e09\u7ec4\u8fc7\u53bb\u72ec\u7acb\u53d1\u8868\u7684\u6d41\u611f\u5bbf\u4e3b\u56e0\u5b50\u5217\u8868\u4e3a\u4f8b\u8fdb\u884c\u8bf4\u660e\u3002<\/p>\n\n\n\n

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\u56fe3. a\uff09 Metascape\u7528heatmap\u8ba9\u4e09\u7ec4\u6570\u636e\u96c6\u5171\u4eab\u7684\u548c\u72ec\u7279\u7684\u751f\u7269\u901a\u8def\u4e00\u76ee\u4e86\u7136\u3002b\uff09\u5bcc\u96c6\u901a\u8def\u4e5f\u53ef\u4ee5\u4ee5\u7f51\u7edc\u5448\u73b0\u3002\u7531\u4e8e\u6bcf\u4e00\u7ec4\u5bbf\u4e3b\u56e0\u5b50\u7528\u4e00\u4e2a\u72ec\u7279\u7684\u989c\u8272\u8868\u793a\uff0c\u6211\u4eec\u53ef\u4ee5\u5f88\u6e05\u695a\u7684\u53d1\u73b0Viral gene expression\u662f\u5171\u4eab\u7684\u800cRegulation of cell development\u4e3b\u8981\u53ea\u5b58\u5728\u4e8e\u7eff\u8272\u5bf9\u5e94\u7684\u5b9e\u9a8c\u4e2d\u3002<\/figcaption><\/figure>\n\n\n\n

Metascape\u7684\u56fe\u8868\u4e3a\u751f\u7269\u5b66\u8005\u63d0\u4f9b\u4e86\u4e00\u4e9b\u5bf9\u9610\u8ff0\u7ed3\u8bba\u975e\u5e38\u6709\u6548\u7684\u6570\u636e\u8868\u8fbe\u5f62\u5f0f\u3002\u6709\u7684\u8bba\u6587\u751a\u81f3\u591a\u5904\u91c7\u7528Metascape\u7684\u56fe\u5f62\uff0c\u6bd4\u5982\u56fe4\u4e2d\u7684\u4e24\u4e2a\u4f8b\u5b50\u3002 \u8bfb\u8005\u5728\u4ee5\u540e\u9605\u8bfb\u6587\u732e\u4e2d\u53ef\u80fd\u4f1a\u4e0d\u65f6\u9047\u5230Metascape\u98ce\u683c\u7684\u56fe\u8868\u3002 <\/p>\n\n\n\n

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\u56fe4. \uff41\uff09\u6458\u81eaLotan et al. Molecular Psychiatry (2018) 78:865\u4e2d\u7684Figure 5; b\uff09\u6458\u81eaDong et al. Genome Biol (2018) 19:31\u4e2d\u7684Figure 3\u3002
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\u8bc4\u8bba<\/p>\n\n\n\n

\u5f88\u591a\u5b66\u8005\u8fd8\u5728\u91c7\u7528DAVID\u505a\u5bcc\u96c6\u901a\u8def\u5206\u6790\u3002\u5bcc\u96c6\u901a\u8def\u5206\u6790\u7ed3\u679c\u5b8c\u5168\u4f9d\u8d56\u4e8e\u80cc\u540e\u6570\u636e\u5e93\u7684\u8d28\u91cf\u3002DAVID\u66fe\u7ecf\u6709\u516d\u5e74\u7684\u65f6\u95f4\uff082010-2016\uff09\u6ca1\u6709\u7ef4\u62a4\u6570\u636e\u5e93\uff0c\u6700\u8fd1\u7684\u66f4\u65b0\u4e5f\u5df2\u7ecf\u4e24\u5e74\u534a\u4e86\u3002\u72ec\u7acb\u7814\u7a76\u8868\u660e\u4f7f\u7528\u4e24\u5e74\u65e7\u7684Gene ontology\u6570\u636e\u5e93\uff0c\u7528\u6237\u5e73\u5747\u8981\u4e22\u593120%\u7684\u6700\u65b0\u7684\u751f\u7269\u77e5\u8bc6\u3002\u6240\u4ee5\u5b9a\u671f\u66f4\u65b0\u6570\u636e\u5e93\u7684\u91cd\u8981\u6027\u975e\u540c\u5c0f\u53ef\u3002\u53ef\u60dc\u73b0\u5b9e\u662f\u76ee\u524d\u5927\u5bb6\u5e38\u4f7f\u7528\u5bcc\u96c6\u5206\u6790\u5de5\u5177\u4e2d\u4ec5\u670940%\u88ab\u6b63\u5e38\u7ef4\u62a4\uff0c\u4e0d\u77e5\u8bfb\u8005\u76ee\u524d\u4f7f\u7528\u7684\u5de5\u5177\u662f\u5426\u5c5e\u4e8e\u5e78\u8fd0\u7684\u4e00\u7c7b\u3002Metascape\u6bcf\u6708\u66f4\u65b0\u80cc\u540e\u768440\u591a\u4e2a\u6570\u636e\u5e93\uff0c\u4ee5\u786e\u4fdd\u63d0\u4f9b\u6700\u51c6\u786e\u7684\u7ed3\u679c\u3002<\/p>\n\n\n\n

Metascape\u6ca1\u6709\u5b66\u4e60\u4f7f\u7528\u7684\u58c1\u5792\uff0c\u56e0\u4e3a\u6ca1\u6709\u6bd4\u4e00\u952eExpress Analysis\u66f4\u7b80\u5355\u4e86\u3002 \u867d\u7136\u597d\u7528\uff0cMetascape\u5b9e\u73b0\u7684\u4e3b\u8981\u529f\u80fd\u5374\u662f\u4e0d\u6298\u4e0d\u6263\u3002\u4f5c\u8005\u7531\u4e8e\u591a\u5e74\u6765\u5728\u81ea\u5df1\u7684\u79d1\u7814\u9879\u76ee\u4e2d\u90fd\u8981\u82b1\u5927\u91cf\u7684\u65f6\u95f4\u8fdb\u884c\u8fd9\u4e9b\u751f\u7269\u4fe1\u606f\u5206\u6790\uff0c\u6240\u4ee5\u51b3\u5b9a\u628a\u957f\u671f\u53d1\u8868\u6587\u7ae0\u4e2d\u4f53\u4f1a\u5230\u7684best practices\u5b9e\u73b0\u5728Metascape\u4e2d\u3002\u7531\u4e8e\u5e38\u7528\u7684\u57fa\u56e0\u5217\u8868\u7684\u5206\u6790\u5de5\u5177\u4ec5\u9650\u4e8e\u63d0\u4f9b\u5355\u4e00\u901a\u8def\u5bcc\u96c6\u5206\u6790\uff0c\u8fd9\u5c31\u4e0d\u5e78\u7ed9\u7814\u7a76\u4eba\u5458\u9020\u6210\u4e86\u5217\u8868\u5206\u6790\u5c31\u662f\u7b49\u540c\u4e8e\u77e5\u8bc6\u9a71\u52a8\u7684\u5bcc\u96c6\u5206\u6790\u7684\u8bef\u89e3\u3002\u800c\u6570\u636e\u9a71\u52a8\u7684\u86cb\u767d\u8d28\u4e92\u4f5c\u7528\u7f51\u7edc\u5206\u6790\u5c31\u9c9c\u6709\u7f51\u7ad9\u652f\u6301\u3002\u5176\u5b9e\u9664\u4e86\u4ee5\u4e0a\u63cf\u8ff0\u7684Metascape\u63d0\u4f9b\u7684\u6797\u6797\u603b\u603b\u7684\u5206\u6790\u529f\u80fd\u4e4b\u5916\uff0c\u5176\u8fd8\u6709\u975e\u5e38\u5f3a\u5927\u7684\u5bf9\u4e0a\u5343\u4e2a\u57fa\u56e0\u8fdb\u884c\u6ce8\u91ca\u6216\u8005\u5229\u7528\u77e5\u8bc6\u5e93\u8fdb\u884c\u6210\u5458\u5206\u6790\u7684\u529f\u80fd\uff0c\u8fd9\u4e9b\u5bf9\u4e8e\u540e\u7eed\u7684\u57fa\u56e0\u7b5b\u9009\u53ca\u5176\u91cd\u8981\uff0c\u8be6\u60c5\u8bf7\u89c1\u6587\u7ae0\u6216\u7f51\u7ad9\u6587\u6863\u3002\u8981\u5b9e\u73b0Metascape\u7684\u8fd9\u4e9b\u5206\u6790\u529f\u80fd\u5bf9\u4e8e\u751f\u7269\u4fe1\u606f\u4eba\u5458\u90fd\u662f\u6709\u96be\u5ea6\u7684\u3002<\/p>\n\n\n\n

Metascape\u7f51\u7ad9\u5728\u6587\u7ae0\u53d1\u8868\u4e4b\u524d\u5c31\u5df2\u7ecf\u88ab350\u591a\u7bc7\u8bba\u6587\u5f15\u7528\uff0c\u5176\u4e2d\u4e0d\u4e4f\u300a\u81ea\u7136\u300b\uff0c\u300a\u79d1\u5b66\u300b\uff0c\u300a\u7ec6\u80de\u300b\u7b49\u6742\u5fd7\u3002\u6709\u8da3\u7684\u662f\u7ea6\u4e09\u5206\u4e4b\u4e8c\u7684\u5f15\u7528\u6587\u7ae0\u4f7f\u7528\u4e86Metascape\u751f\u6210\u7684\u56fe\u8868\u3002\u8fd9\u53ef\u80fd\u8981\u5f52\u529f\u4e8e\u8fd9\u4e9b\u56fe\u8868\u7684\u8bbe\u8ba1\u90fd\u662f\u57fa\u4e8e\u4f5c\u8005\u56e2\u961f\u591a\u5e74\u53d1\u8868\u8bba\u6587\u7684\u7ecf\u9a8c\u4e4b\u4e0a\uff0c\u6240\u4ee5\u624d\u6709\u4e86\u56fe\uff14\u8fd9\u6837\u7684\u4f8b\u5b50\u3002<\/p>\n\n\n\n

\u6211\u4eec\u9f13\u52b1\u751f\u7269\u7814\u7a76\u8005\u4eec\u5c1d\u8bd5\u4e00\u4e0bMetascape\uff0c\u518d\u540c\u5404\u81ea\u76ee\u524d\u4f7f\u7528\u7684\u5de5\u5177\u505a\u4e2a\u6bd4\u8f83\u3002\u5982\u679cMetascape\u5bf9\u5927\u5bb6\u79d1\u7814\u6548\u7387\u7684\u63d0\u9ad8\u6709\u6240\u5e2e\u52a9\uff0c\u6211\u4eec\u5236\u4f5c\u7f51\u7ad9\u7684\u521d\u8877\u5c31\u5b9e\u73b0\u4e86\u3002\u5bf9Metascape\u7684\u80cc\u666f\u611f\u5174\u8da3\u7684\u8bfb\u8005\uff0c\u53ef\u4ee5\u9605\u8bfb\u53e6\u4e00\u7bc7<\/a>\u7684\u535a\u5ba2\u3002\u6211\u4eec\u6700\u8fd1\u7279\u610f\u5c06\u535a\u5ba2\u642c\u4e86\u5bb6\uff0c\u4ee5\u4fbf\u4e2d\u56fd\u8bfb\u8005\u53ef\u4ee5\u8bbf\u95ee\u5230\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u6b22\u8fce\u8f6c\u8f7d \u80cc\u666f \u5206\u6790\u57fa\u56e0\u6216\u86cb\u767d\u8d28\u7ec4\u5b66\u7684\u6570\u636e\u5e76\u975e\u6613\u4e8b\u4e00\u4ef6\u3002\u76ee\u524d\u7684\u57fa\u56e0\u5217\u8868\u5206\u6790\u7f51\u7ad9\u5927\u591a\u5c40\u9650\u4e8e\u901a\u8def\u7684\u5bcc\u96c6\u5206\u6790\uff0c\u5e76\u672a\u5b8c\u5168\u6316\u6398\u57fa\u56e0\u7ec4\u89c4\u6a21\u6570\u636e\u96c6\u7684\u4ef7\u503c\u3002\u800c\u66f4\u5168\u9762\u7684\u5206\u6790\u5bf9\u6ca1\u6709\u751f\u7269\u4fe1\u606f\u961f\u53cb\u7684\u751f\u7269\u5b66\u8005\u800c\u8a00\u5f80\u5f80\u662f\u53ef\u671b\u4e0d\u53ef\u53ca\u3002\u5728\u9762\u5bf9\u5927\u91cf\u57fa\u56e0\u7ec4\u6570\u636e\u96c6\u7684\u5927\u6570\u636e\u65f6\u4ee3\uff0cMetascape\u7f51\u7ad9\uff08http:\/\/metascape.org\uff09\u53ca\u65f6\u4e3a\u751f\u7269\u5b66\u5bb6\u63d0\u4f9b\u4e86\u4e00\u79cd\u7b80\u6d01\u7684\u65b9\u5f0f\u6765\u66f4\u6709\u6548\u5730\u7406\u89e3\u5b9e\u9a8c\u6570\u636e\u3002Metascape\u56e2\u961f\u5728Nature Communications\u4e0a\u53d1\u8868\u4e86\u9898\u4e3a\uff1a \u201cMetascape provides a biologist-oriented resource for the analysis of systems-level datasets\u201d \u7684\u6587\u7ae0\uff08 DOI: 10.1038\/s41467-019-09234-6 \uff09\u3002 \u4ecb\u7ecd Metascape\u96c6\u6210\u4e86\u56db\u5341\u591a\u4e2a\u751f\u7269\u4fe1\u606f\u6570\u636e\u5e93\uff0c\u901a\u8fc7\u4e00\u952e\u5feb\u901f\u5206\u6790\u7684\u7b80\u6d01\u754c\u9762\u8ba9\u751f\u7269\u5b66\u8005\u80fd\u591f\u8f7b\u677e\u83b7\u5f97\u5168\u9762\u7684\u6570\u636e\u89e3\u6790\u3002 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Analysis\u6309\u94ae\u5373\u53ef\u3002Metascape\u80fd\u81ea\u52a8\u8bc6\u522b\u5e38\u7528\u7684\u5404\u79cd\u57fa\u56e0\u6216\u86cb\u767d\u8d28\u7684\u6807\u8bc6\u7b26\u3002\u5206\u6790\u5b8c\u6210\u540e\u7f51\u9875\u4f1a\u5f15\u5bfc\u7528\u6237\u6253\u5f00\u4e00\u4efd\u5206\u6790\u62a5\u544a\u3002\u5206\u6790\u62a5\u544a\u6a21\u4eff\u79d1\u7814\u8bba\u6587\u7684\u683c\u5f0f\u6765\u5c55\u73b0\u5206\u6790\u7ed3\u679c\uff0c\u56fe\u6587\u5e76\u8302\uff0c\u5bf9\u751f\u7269\u5b66\u8005\u6781\u5176\u53cb\u597d\u3002\u62a5\u544a\u4e2d\u8be6\u7ec6\u9610\u8ff0\u4e86\u5206\u6790\u65b9\u6cd5\u548c\u56fe\u5f62\u7684\u610f\u4e49\uff0c\u800c\u4e14\u56fe\u5f62\u90fd\u542b\u53ef\u4ee5\u53d1\u8868\u7684\u9ad8\u6e05\u6670\u6587\u4ef6\u683c\u5f0f\u3002\u62a5\u544a\u8fd8\u63d0\u4f9b\u4e86\u683c\u5f0f\u5316\u597d\u7684Excel\u6587\u4ef6\uff0c\u8bb8\u591a\u6587\u7ae0\u76f4\u63a5\u4f7f\u7528\u5b83\u505asupplementary table\u3002\u81ea\u52a8\u751f\u6210\u7684PowerPoint\u6587\u4ef6\u65b9\u4fbf\u5b66\u8005\u4eec\u4ea4\u6d41\u7ed3\u679c\u3002\u6240\u6709\u7684\u6570\u636e\u548c\u56fe\u6807\u6587\u4ef6\u90fd\u53ef\u4ee5\u901a\u8fc7\u4e00\u4e2aZip\u6587\u4ef6\u5305\u4e0b\u8f7d\u4fdd\u5b58\u3002\u86cb\u767d\u8d28\u7f51\u7edc\u6587\u4ef6\u683c\u5f0f\u8fd8\u652f\u6301\u7528\u7b2c\u4e09\u65b9\u8f6f\u4ef6\u6bd4\u5982Cytoscape\u8fdb\u884c\u66f4\u52a0\u6df1\u5165\u7684\u5206\u6790\u3002\u7528\u6237\u719f\u6089\u540e\u4e5f\u53ef\u4ee5\u4f7f\u7528Custom Analysis\u6309\u94ae\u5bf9\u66f4\u591a\u7684\u5206\u6790\u529f\u80fd\u548c\u53c2\u6570\u4e88\u4ee5\u8c03\u8282\u3002 \u56fe2\u4ee5121\u4e2a\u6d41\u611f\u5bbf\u4e3b\u56e0\u5b50\u4e3a\u4f8b\uff0c\u8bf4\u660e\u4e86Metascape\u5bf9\u5355\u4e00\u57fa\u56e0\u5217\u8868\u7684\u4e3b\u8981\u5206\u6790\u7ed3\u679c\u3002 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